Lofepramine

Lofepramine is a tricyclic antidepressant (TCA) that is used in the treatment of depression. It is a third-generation TCA and is marketed in various countries worldwide, including the United Kingdom, Belgium, Ireland, and South Africa. Lofepramine is less sedating and has less anticholinergic effects than other TCAs.

Pharmacology[edit | edit source]

Lofepramine functions by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin. This increases the concentration of these neurotransmitters in the synaptic cleft, leading to increased neurotransmission. Lofepramine is metabolized in the liver to desipramine, another TCA, which is thought to contribute to its antidepressant effect.

Side Effects[edit | edit source]

Common side effects of lofepramine include dry mouth, blurred vision, dizziness, tachycardia, constipation, urinary retention, and weight gain. Less common side effects include confusion, hallucinations, delirium, and orthostatic hypotension.

Interactions[edit | edit source]

Lofepramine can interact with a number of other medications, including other antidepressants, antipsychotics, antihypertensives, and anticholinergic drugs. It can also interact with alcohol, leading to increased sedation.

Contraindications[edit | edit source]

Lofepramine is contraindicated in individuals with a history of hypersensitivity to it or to other TCAs. It is also contraindicated in individuals with a history of cardiac arrhythmias, recent myocardial infarction, or any degree of heart block.

See Also[edit | edit source]

Lofepramine Resources
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