N-Methyl-3-piperidyl benzilate

N-Methyl-3-piperidyl benzilate (also known as 3-Quinuclidinyl benzilate or BZ) is a potent anticholinergic compound related to the chemical structure of scopolamine. It was developed by the United States in the mid-20th century as a potential chemical warfare agent.

History

N-Methyl-3-piperidyl benzilate was first synthesized in the 1950s as part of a United States military program to develop non-lethal incapacitating agents. The compound was one of a series of anticholinergic compounds tested for their potential use in warfare.

Pharmacology

N-Methyl-3-piperidyl benzilate is a potent anticholinergic, meaning it blocks the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. This can lead to a wide range of effects, including dilated pupils, blurred vision, increased heart rate, dry mouth, urinary retention, and confusion.

Effects

The effects of N-Methyl-3-piperidyl benzilate can vary widely depending on the dose and route of administration. At lower doses, it can cause confusion, disorientation, and hallucinations. At higher doses, it can cause severe delirium and incapacitation. The effects can last for several days.

Use in Warfare

Despite its potential as a chemical warfare agent, N-Methyl-3-piperidyl benzilate has never been used in warfare to the best of our knowledge. Its long duration of action and unpredictable effects make it less suitable for use in warfare than other chemical agents.

Safety

Due to its potent anticholinergic effects, N-Methyl-3-piperidyl benzilate can be dangerous if ingested or inhaled. It is not currently approved for any medical use, and possession of the compound is regulated by international law.

See Also

• Chemical warfare
• Anticholinergic
• Scopolamine