VU-0152099
Overview[edit | edit source]
VU-0152099 is a chemical compound that acts as a selective M1 receptor positive allosteric modulator. It is primarily used in scientific research to study the M1 muscarinic receptor and its role in cognitive function and neurological disorders.
Chemical Structure[edit | edit source]
VU-0152099 is characterized by its unique chemical structure, which allows it to selectively bind to the M1 muscarinic receptor. This selectivity is crucial for its role in modulating receptor activity without affecting other muscarinic receptors.
Mechanism of Action[edit | edit source]
VU-0152099 functions as a positive allosteric modulator of the M1 receptor. This means that it binds to a site on the receptor distinct from the orthosteric site where the endogenous ligand, acetylcholine, binds. By binding to this allosteric site, VU-0152099 enhances the receptor's response to acetylcholine, thereby potentiating its effects.
Research Applications[edit | edit source]
The compound is extensively used in preclinical studies to explore the therapeutic potential of M1 receptor modulation. It has been investigated for its effects on memory, learning, and synaptic plasticity. Researchers are particularly interested in its potential applications in treating Alzheimer's disease and other cognitive disorders.
Pharmacological Effects[edit | edit source]
Studies have shown that VU-0152099 can improve cognitive performance in animal models. It has been observed to enhance long-term potentiation (LTP) in the hippocampus, a brain region critical for memory formation. These effects are attributed to its ability to modulate M1 receptor activity.
Safety and Toxicology[edit | edit source]
As with many research chemicals, the safety profile of VU-0152099 is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented. Researchers must handle it with care, following appropriate safety protocols.
Future Directions[edit | edit source]
The ongoing research aims to better understand the role of M1 receptor modulation in cognitive processes and its potential therapeutic applications. VU-0152099 serves as a valuable tool in this research, helping to elucidate the complex mechanisms underlying neurotransmission and neurodegeneration.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
