A-349821

A-349821 is a potent and selective agonist of the human adenosine A1 receptor. It is used in scientific research to study the role of the A1 receptor in various biological processes.

Chemistry

A-349821 is a small molecule with a molecular weight of approximately 500 g/mol. It is composed of a pyrazole ring attached to a phenyl group, with a sulfonamide group on the other side of the molecule. The exact structure of A-349821 is proprietary information and is not publicly available.

Pharmacology

A-349821 acts as an agonist at the adenosine A1 receptor, meaning it binds to the receptor and activates it. The A1 receptor is one of four known types of adenosine receptors in the human body, the others being the A2A, A2B, and A3 receptors. The A1 receptor is found in many tissues throughout the body, including the brain, heart, and kidneys.

Biological effects

Activation of the A1 receptor by A-349821 has several effects in the body. In the brain, it can inhibit the release of various neurotransmitters, including acetylcholine, dopamine, and glutamate. This can have effects on mood, cognition, and other brain functions. In the heart, A1 receptor activation can slow the heart rate and reduce the force of heart contractions. In the kidneys, it can reduce the rate of urine production.

Research uses

A-349821 is used in scientific research to study the role of the A1 receptor in various biological processes. For example, it has been used to investigate the role of the A1 receptor in the regulation of heart rate and blood pressure, in the control of neurotransmitter release in the brain, and in the regulation of kidney function.

See also

• Adenosine receptor
• Agonist
• Neurotransmitter