Imidafenacin

Imidafenacin is a medication used to treat overactive bladder, a condition characterized by frequent or urgent urination, incontinence (urine leakage), and nocturia (waking up at night to urinate). It belongs to a class of drugs known as anticholinergics, which work by relaxing the muscles in the bladder.

Mechanism of Action

Imidafenacin works by blocking muscarinic acetylcholine receptors in the bladder, reducing the activity of the detrusor muscle. This helps to decrease bladder contractions and increase bladder capacity, thereby reducing symptoms of overactive bladder.

Side Effects

Common side effects of imidafenacin include dry mouth, constipation, and blurred vision. Less common side effects may include urinary retention, dizziness, and cognitive impairment.

Interactions

Imidafenacin may interact with other medications, including other anticholinergics, certain antidepressants, and some antihistamines. It is important to inform your healthcare provider of all medications you are currently taking to avoid potential interactions.

Contraindications

Imidafenacin is contraindicated in individuals with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma. It should also be used with caution in individuals with liver or kidney disease.

Pharmacokinetics

Imidafenacin is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. It is extensively metabolized in the liver, primarily by the enzyme CYP3A4. The elimination half-life is approximately 7-8 hours.

See Also

• Overactive bladder
• Anticholinergic
• Muscarinic acetylcholine receptor
• Detrusor muscle

Imidafenacin Resources
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