Histamine H2 receptor
Histamine H2 receptor is a protein that in humans is encoded by the HRH2 gene. It is a member of the histamine receptor family of G-protein-coupled receptors.
Etymology[edit | edit source]
The term "Histamine" is derived from the Greek words "histos" meaning tissue and "amine" due to its discovery as a product of decarboxylated histidine. The "H2" in "Histamine H2 receptor" refers to the second subtype of histamine receptors discovered.
Function[edit | edit source]
Histamine H2 receptors are primarily found in the parietal cells of the stomach lining where they stimulate gastric acid secretion. They also exist in the brain and heart where they have various effects such as regulating gastric motility and cardiac rhythm.
Clinical significance[edit | edit source]
Histamine H2 receptors play a significant role in gastrointestinal diseases such as peptic ulcer disease and gastroesophageal reflux disease. Drugs that block these receptors, known as H2 antagonists, are commonly used to treat these conditions.
Related terms[edit | edit source]
- Histamine
- Histamine receptor
- H2 antagonist
- Parietal cells
- Gastric acid
- Peptic ulcer disease
- Gastroesophageal reflux disease
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
