Dexetimide

Dexetimide is a medication that belongs to the class of anticholinergic drugs. It is primarily used in the treatment of Parkinson's disease and other conditions that involve extrapyramidal symptoms. Dexetimide works by blocking the action of acetylcholine, a neurotransmitter in the central nervous system.

Medical Uses

Dexetimide is used to manage symptoms of Parkinson's disease, such as tremors, rigidity, and bradykinesia. It is also employed in the treatment of drug-induced extrapyramidal symptoms, which can occur as side effects of certain antipsychotic medications.

Mechanism of Action

Dexetimide exerts its effects by inhibiting the action of acetylcholine on muscarinic receptors in the brain. This helps to restore the balance between acetylcholine and dopamine, which is often disrupted in Parkinson's disease and other conditions involving extrapyramidal symptoms.

Side Effects

Common side effects of dexetimide include dry mouth, blurred vision, constipation, and urinary retention. Less common but more serious side effects can include confusion, hallucinations, and tachycardia.

Contraindications

Dexetimide is contraindicated in individuals with narrow-angle glaucoma, myasthenia gravis, and certain types of cardiovascular disease. It should be used with caution in elderly patients and those with a history of urinary retention or gastrointestinal obstruction.

Dosage and Administration

The dosage of dexetimide varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally in tablet form. The dosage should be adjusted gradually to minimize side effects and achieve the desired therapeutic effect.

Pharmacokinetics

Dexetimide is well-absorbed from the gastrointestinal tract and is metabolized in the liver. It is excreted primarily in the urine.

History

Dexetimide was developed as part of the search for effective treatments for Parkinson's disease and other conditions involving extrapyramidal symptoms. It has been used clinically for several decades.

See Also

• Parkinson's disease
• Anticholinergic
• Extrapyramidal symptoms
• Acetylcholine
• Muscarinic receptor