Timepidium bromide

Timepidium bromide is a muscarinic antagonist with antispasmodic properties. It is used in the treatment of gastrointestinal and urinary tract disorders.

Pharmacology

Timepidium bromide is a quaternary ammonium compound that acts as a competitive antagonist at muscarinic acetylcholine receptors. It is used primarily for its antispasmodic effects on the gastrointestinal tract. The drug has been shown to inhibit the action of acetylcholine at postganglionic parasympathetic nerve endings, resulting in relaxation of smooth muscle in the gastrointestinal and urinary tracts.

Clinical Use

Timepidium bromide is used in the treatment of a variety of gastrointestinal disorders, including irritable bowel syndrome (IBS), peptic ulcer disease, and gastroesophageal reflux disease (GERD). It is also used in the management of urinary tract disorders such as overactive bladder.

Side Effects

The most common side effects of timepidium bromide are related to its anticholinergic activity. These may include dry mouth, blurred vision, constipation, and urinary retention. In rare cases, the drug may cause allergic reactions or cardiac arrhythmias.

Contraindications

Timepidium bromide is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with glaucoma, myasthenia gravis, and certain types of cardiac arrhythmias.

See Also

• Muscarinic antagonist
• Antispasmodic
• Gastrointestinal tract
• Urinary tract