Phenglutarimide

Phenglutarimide is a sedative and antihistamine drug that was never marketed. It is an analogue of glutethimide, a sedative hypnotic drug. Phenglutarimide has similar sedative and antihistamine effects to glutethimide, but is less potent and has a longer duration of action.

Pharmacology

Phenglutarimide acts as a GABA receptor agonist. It enhances the action of GABA, a neurotransmitter that inhibits the activity of nerve cells in the brain. This results in sedative and antihistamine effects.

Chemistry

Phenglutarimide is a derivative of glutethimide. It is synthesized by the reaction of phenylacetic acid and glutaric anhydride in the presence of a base.

History

Phenglutarimide was first synthesized in the 1960s as a potential sedative and antihistamine drug. However, it was never marketed due to its lower potency and longer duration of action compared to other drugs in its class.

See also

• Glutethimide
• Phenylacetic acid
• GABA receptor

Phenglutarimide Resources
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