Roxatidine

Roxatidine is a pharmacological agent that belongs to the class of H2 receptor antagonists, which are used primarily to treat peptic ulcers, gastroesophageal reflux disease (GERD), and conditions where reduction of gastric acid secretion is required.

Mechanism of Action

Roxatidine works by selectively blocking histamine H2 receptors on the parietal cells of the stomach, leading to a decrease in gastric acid secretion. This action helps in the healing of ulcers and reduction of acid reflux symptoms.

Pharmacokinetics

The absorption of roxatidine is quick and efficient after oral administration. It undergoes minimal metabolism in the liver, with the majority of the drug excreted unchanged in the urine. This pharmacokinetic profile makes it suitable for patients with varying degrees of hepatic function.

Clinical Uses

Roxatidine is primarily used for:

• Treatment of peptic ulcer disease
• Management of gastroesophageal reflux disease (GERD)
• Conditions requiring a reduction in acid secretion

Side Effects

Common side effects of roxatidine include:

• Headache
• Dizziness
• Gastrointestinal disturbances such as nausea and constipation

Comparison with Other H2 Antagonists

Roxatidine is similar in efficacy to other H2 receptor antagonists like ranitidine and famotidine, but it may offer advantages in terms of fewer drug interactions and a slightly different side effect profile.

Regulatory Status

The availability and approval of roxatidine can vary by country, with some regions having discontinued its use while others continue to prescribe it under various brand names.

See Also

• Histamine H2 receptor
• Parietal cells
• Peptic ulcer
• Gastroesophageal reflux disease