Alvameline

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

Alvameline


Alvameline (also known as LU 25-109) is a molecule that acts as a mixed muscarinic acetylcholine receptor agonist and M1 allosteric agonist. It was developed by Lundbeck for the treatment of Alzheimer's disease, but its development was discontinued after phase II clinical trials.

Chemistry[edit | edit source]

Alvameline is a quinuclidine derivative. It is chemically known as (3R,4R)-3-ethyl-4-((1-methyl-1H-imidazol-4-yl)methyl)dodecahydro-2H-pyrido[3,4-b][1,4]oxazin-2-one. Its molecular formula is C14H26N4O2.

Pharmacology[edit | edit source]

Alvameline has a high affinity for muscarinic acetylcholine receptors. It acts as a full agonist at the M1 and M2 subtypes, and as a partial agonist at the M3, M4, and M5 subtypes. The M1 allosteric agonism of Alvameline is thought to enhance its efficacy in the treatment of Alzheimer's disease.

Clinical Trials[edit | edit source]

Alvameline was tested in phase II clinical trials for the treatment of Alzheimer's disease. However, the development was discontinued due to lack of efficacy in improving cognitive function in patients.

See Also[edit | edit source]

References[edit | edit source]

FlattenedRoundPills.jpg
This article is a stub related to pharmacology. You can help WikiMD by expanding it!


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD