Methantheline

Methantheline is a muscarinic antagonist with antispasmodic properties. It is used in the treatment of peptic ulcer disease and in the management of gastrointestinal disorders characterized by abnormal smooth muscle function.

Pharmacology

Methantheline is a quaternary ammonium compound that acts as a competitive antagonist at muscarinic acetylcholine receptors. It inhibits the action of acetylcholine on smooth muscle, glands, and the central nervous system (CNS). Methantheline has a direct effect on smooth muscle and inhibits the motility of the gastrointestinal tract.

Clinical Use

Methantheline is used to treat a variety of gastrointestinal disorders, including irritable bowel syndrome (IBS), peptic ulcer disease, and gastroesophageal reflux disease (GERD). It is also used to relieve symptoms of bladder instability associated with voiding problems.

Side Effects

Common side effects of methantheline include dry mouth, blurred vision, and urinary retention. Less common side effects include tachycardia, palpitations, and constipation. Methantheline can also cause confusion and hallucinations in the elderly.

Contraindications

Methantheline is contraindicated in patients with glaucoma, myasthenia gravis, and severe ulcerative colitis. It should be used with caution in patients with cardiac disease, liver disease, and kidney disease.

Drug Interactions

Methantheline may interact with other drugs, including anticholinergic drugs, antihistamines, and tricyclic antidepressants. These interactions can increase the risk of side effects.

See Also

• Muscarinic antagonist
• Peptic ulcer disease
• Gastrointestinal disorders
• Irritable bowel syndrome
• Gastroesophageal reflux disease