Dizocilpine

From WikiMD's Wellness Encyclopedia

Chemical compound


Dizocilpine
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number 77086-22-7
PubChem 3686
DrugBank DB01427
ChemSpider 3558
KEGG D07865


Dizocilpine, also known as MK-801, is a non-competitive antagonist of the NMDA receptor, a type of glutamate receptor in the central nervous system. It is known for its role in neuroscience research and has been used extensively to study the pathophysiology of neurodegenerative diseases and neuroprotection.

Mechanism of Action[edit | edit source]

Dizocilpine binds to the NMDA receptor at the phencyclidine (PCP) site, blocking the flow of calcium ions through the ion channel. This inhibition prevents the excitotoxicity that can result from excessive glutamate activity, which is implicated in various neurological disorders.

Research Applications[edit | edit source]

Dizocilpine is widely used in preclinical research to investigate the role of NMDA receptors in synaptic plasticity, learning, and memory. It has also been employed in studies of stroke, traumatic brain injury, and schizophrenia.

Side Effects and Toxicity[edit | edit source]

Due to its potent effects on the central nervous system, dizocilpine can cause significant neurotoxicity and behavioral changes in animal models. These effects limit its potential for therapeutic use in humans.

See Also[edit | edit source]

Medicine-stub.png
This article is a stub related to medicine. You can help WikiMD by expanding it!


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD