Apraclonidine
An article about the medication Apraclonidine
Apraclonidine[edit | edit source]
Apraclonidine is a medication primarily used in the treatment of glaucoma and to prevent or reduce intraocular pressure (IOP) following certain types of eye surgery. It is an alpha-2 adrenergic receptor agonist that works by decreasing the production of aqueous humor and increasing its outflow from the eye.
Mechanism of Action[edit | edit source]
Apraclonidine acts as an alpha-2 adrenergic agonist, which means it binds to alpha-2 adrenergic receptors in the eye. This binding results in a decrease in the production of aqueous humor by the ciliary body and an increase in uveoscleral outflow, thereby reducing intraocular pressure. The reduction in IOP helps to prevent damage to the optic nerve and loss of vision in patients with glaucoma.
Clinical Uses[edit | edit source]
Apraclonidine is used in the management of open-angle glaucoma and ocular hypertension. It is also employed to control or prevent spikes in intraocular pressure following laser eye surgery such as laser trabeculoplasty or laser iridotomy.
Administration[edit | edit source]
Apraclonidine is typically administered as an ophthalmic solution, with the usual concentration being 0.5% for long-term use and 1% for short-term use, such as post-surgical applications. Patients are advised to apply the drops directly into the affected eye(s) as prescribed by their healthcare provider.
Side Effects[edit | edit source]
Common side effects of apraclonidine include dry mouth, ocular hyperemia, eye discomfort, and allergic reactions. Less common but more serious side effects can include bradycardia, hypotension, and central nervous system effects such as drowsiness and fatigue.
Contraindications[edit | edit source]
Apraclonidine is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with severe cardiovascular disease, as apraclonidine can affect heart rate and blood pressure.
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