Nitromethaqualone

Nitromethaqualone is a quinazolinone class GABAergic drug which was developed in the 1960s and 1970s as a sedative and muscle relaxant. It is related to Methaqualone, a well-known sedative-hypnotic drug, but was never marketed.

Chemistry

Nitromethaqualone differs from methaqualone by the addition of a 2-nitro group on the phenyl ring. It has CNS depressant properties.

Pharmacology

Nitromethaqualone acts as a GABA_A receptor positive allosteric modulator. The nitro group of nitromethaqualone is a crucial part of its pharmacology, as it is not active without it.

History

Nitromethaqualone was developed in the 1960s and 1970s as part of a series of quinazolinone class drugs. However, it was never marketed due to its potential for misuse and addiction.

Legal Status

Nitromethaqualone is currently a Schedule I controlled substance in the United States due to its high potential for abuse and addiction.

See Also

• Methaqualone
• Quinazolinone
• GABA_A receptor

Nitromethaqualone Resources
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