Piquindone

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Piquindone

Piquindone is a type of antipsychotic medication that belongs to the quinazolinone class of drugs. It was developed in the 1980s and is primarily used in the treatment of schizophrenia and other psychotic disorders.

History

Piquindone was first synthesized in the 1980s by the pharmaceutical company Janssen Pharmaceutica. It was developed as part of a series of quinazolinone derivatives designed to treat psychotic disorders. Despite its promising initial results, piquindone has not been widely adopted in clinical practice.

Pharmacology

Piquindone acts as a dopamine antagonist, blocking the action of dopamine in the brain. This helps to reduce the symptoms of psychosis, such as hallucinations and delusions. It also has some serotonin antagonist properties, which can help to reduce the negative symptoms of schizophrenia, such as apathy and social withdrawal.

Clinical Use

Piquindone is used in the treatment of schizophrenia and other psychotic disorders. It can be used alone or in combination with other antipsychotic medications. The dosage of piquindone is typically adjusted based on the patient's response and tolerance to the medication.

Side Effects

Like all antipsychotic medications, piquindone can cause side effects. These can include drowsiness, dizziness, and nausea. In rare cases, piquindone can cause serious side effects such as tardive dyskinesia, a condition characterized by involuntary movements of the face and body.

See Also

• Antipsychotic
• Schizophrenia
• Quinazolinone
• Dopamine antagonist
• Serotonin antagonist