Carpindolol

Overview of the beta-blocker Carpindolol

Carpindolol
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Carpindolol is a beta-blocker medication used primarily in the treatment of hypertension and certain types of cardiac arrhythmias. It is known for its ability to block beta-adrenergic receptors, which are part of the sympathetic nervous system.

Pharmacology

Carpindolol functions by inhibiting the action of epinephrine and norepinephrine on beta-adrenergic receptors. This leads to a decrease in heart rate, cardiac output, and blood pressure. The drug is classified as a non-selective beta-blocker, meaning it affects both beta-1 and beta-2 receptors.

Mechanism of Action

Structural formula of Carpindolol

Carpindolol binds to beta-adrenergic receptors on the surface of cells in the heart and vascular smooth muscle. By blocking these receptors, it prevents the usual binding of catecholamines, which are responsible for increasing heart rate and force of contraction. This results in a reduction of myocardial oxygen demand and a decrease in blood pressure.

Clinical Uses

Carpindolol is primarily used in the management of:

• Hypertension
• Angina pectoris
• Cardiac arrhythmias
• Heart failure

Side Effects

Common side effects of Carpindolol include:

• Bradycardia
• Fatigue
• Dizziness
• Cold extremities

Less common but more serious side effects can include:

• Bronchospasm
• Heart block
• Hypotension

Contraindications

Carpindolol should not be used in patients with:

• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Severe bradycardia
• Cardiogenic shock

Related pages

• Beta-blocker
• Hypertension
• Cardiac arrhythmia
• Adrenergic receptor