Beta-1 adrenergic receptor

Beta-1 adrenergic receptor (β1 adrenoceptor) is a type of adrenergic receptor that is primarily associated with cardiac muscle contraction. It is a G protein-coupled receptor located mainly in the heart and in the kidney.

Structure

The β1 adrenergic receptor is a member of the G protein-coupled receptor superfamily. It is composed of 477 amino acids and has a molecular weight of approximately 51.4 kDa. The receptor is made up of seven transmembrane domains, an extracellular N terminus, and an intracellular C terminus.

Function

The primary function of the β1 adrenergic receptor is to mediate the effects of the catecholamines epinephrine and norepinephrine in the heart and kidneys. Activation of the receptor leads to an increase in heart rate, myocardial contractility, and renin release from the kidneys.

Clinical significance

The β1 adrenergic receptor is a target for several classes of cardiovascular drugs, including beta blockers, which are used to treat conditions such as hypertension, angina, and heart failure. Mutations in the gene encoding the β1 adrenergic receptor have been associated with familial atrial fibrillation and dilated cardiomyopathy.

See also

• Adrenergic receptor
• Beta blocker
• G protein-coupled receptor
• Heart failure
• Hypertension

References

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