Pinoxepin
Pinoxepin is a tricyclic antidepressant (TCA) that was developed in the 1960s but was never marketed. It is structurally related to other tricyclic antidepressants such as amitriptyline and doxepin.
Pharmacology[edit | edit source]
Pinoxepin acts as a potent serotonin and norepinephrine reuptake inhibitor, with additional antihistamine, anticholinergic, and antiadrenergic properties. It is known to block the reuptake of serotonin and norepinephrine, thereby increasing the levels of these neurotransmitters in the brain and enhancing their effects.
Chemistry[edit | edit source]
Pinoxepin is a tricyclic compound, meaning it contains three rings of atoms in its chemical structure. It is structurally similar to other tricyclic antidepressants, which also contain three rings of atoms. The chemical formula of pinoxepin is C19H21NO.
History[edit | edit source]
Pinoxepin was developed in the 1960s as part of a series of tricyclic antidepressants. Despite showing promise in early trials, it was never marketed, possibly due to the development of newer, safer antidepressants.
See also[edit | edit source]
The following are antidepressant subclasses and drugs
MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine
SNRIs Duloxetine, Levomilnacipran, Venlafaxine
SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine
Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine
Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone
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