Nordoxepin

Nordoxepin is a tricyclic antidepressant (TCA) and the major active metabolite of the antidepressant drug doxepin. It is used in the treatment of various mental health disorders including depression, anxiety disorders, and insomnia.

Pharmacology

Nordoxepin acts by inhibiting the reuptake of serotonin and norepinephrine, thereby increasing the levels of these neurotransmitters in the brain. It also has significant antihistamine activity, which contributes to its sedative effects.

Clinical Use

Nordoxepin is used primarily in the treatment of depression and anxiety disorders. It is also used off-label for the treatment of chronic pain and insomnia. The drug has a slow onset of action, with therapeutic effects typically seen after 2-4 weeks of treatment.

Side Effects

Common side effects of Nordoxepin include drowsiness, dry mouth, constipation, and blurred vision. More serious side effects can include cardiac arrhythmias, orthostatic hypotension, and serotonin syndrome when used in combination with other serotonergic drugs.

Interactions

Nordoxepin can interact with a number of other medications, including other antidepressants, antipsychotics, and certain heart medications. It is also contraindicated in patients with a history of cardiac arrhythmias or those who are currently taking monoamine oxidase inhibitors (MAOIs).

See Also

• Doxepin
• Tricyclic antidepressant
• Serotonin
• Norepinephrine

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