Dopexamine
Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce inflammation and to treat severe heart failure and acute kidney injury. Its primary use is in hospitals, where it is usually administered as a continuous intravenous infusion.
Pharmacology[edit | edit source]
Dopexamine stimulates beta-2 adrenergic receptors and, to a lesser extent, beta-1 adrenergic receptors, with the effect of reducing systemic vascular resistance. It also stimulates dopamine receptors in the kidneys, increasing urine output, which is beneficial in preventing renal failure. Dopexamine has no significant action on alpha adrenergic receptors, so it does not cause vasoconstriction.
Clinical Use[edit | edit source]
Dopexamine is used primarily in the treatment of heart failure and acute kidney injury. It is also used in the management of low cardiac output syndrome, particularly following cardiac surgery. Dopexamine has been shown to reduce the incidence of low cardiac output syndrome in patients undergoing coronary artery bypass surgery.
Side Effects[edit | edit source]
The most common side effects of dopexamine include tachycardia, hypotension, and arrhythmia. Less common side effects include nausea, vomiting, and diarrhea. Rare but serious side effects include myocardial ischemia and ventricular fibrillation.
Contraindications[edit | edit source]
Dopexamine is contraindicated in patients with pheochromocytoma, as it may provoke a hypertensive crisis. It is also contraindicated in patients with uncorrected tachyarrhythmia or ventricular fibrillation.
See Also[edit | edit source]
Drug groups | Encyclopedia | Dictionary | Cancer drugs | OTC | Alternative meds | Drugs | Medications A-Z | FDA approved products | Portal:Pharmacology
Cardiovascular disease A-Z
Most common cardiac diseases
- Cardiac arrhythmia
- Cardiogenetic disorders
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- Heart neoplasia
- Ischemic heart diseases
- Pericardial disorders
- Syndromes affecting the heart
- Valvular heart disease
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
A[edit source]
- Accelerated idioventricular rhythm
- Acute decompensated heart failure
- Arteriosclerotic heart disease
- Athletic heart syndrome
- Atrial flutter
- Atrioventricular fistula
- Cardiovascular disease in Australia
- Autoimmune heart disease
B[edit source]
C[edit source]
- Ebb Cade
- Cardiac allograft vasculopathy
- Cardiac amyloidosis
- Cardiac asthma
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- Coxsackievirus-induced cardiomyopathy
D[edit source]
E[edit source]
H[edit source]
- Heart attack
- Heart failure
- Heart failure with preserved ejection fraction
- Heart to Heart (1949 film)
- High-output heart failure
- Hyperdynamic precordium
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
I[edit source]
- Idiopathic giant-cell myocarditis
- Interventricular dyssynchrony
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- Isolated atrial amyloidosis
K[edit source]
L[edit source]
M[edit source]
- Mydicar
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N[edit source]
O[edit source]
P[edit source]
- Papillary fibroelastoma
- Pathophysiology of heart failure
- Postpericardiotomy syndrome
- Pulmonary vein stenosis
R[edit source]
S[edit source]
- Saturated fat and cardiovascular disease
- SCAR-Fc
- Shone's syndrome
- Strain pattern
- Subacute bacterial endocarditis
- Sudden cardiac death of athletes
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
T[edit source]
V[edit source]
W[edit source]
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