OLR1

OLR1 (Oxidized Low Density Lipoprotein Receptor 1), also known as LOX-1, is a protein that in humans is encoded by the OLR1 gene. It is a type I membrane protein that is involved in the metabolism of low density lipoproteins (LDLs), including the recognition and binding of oxidized LDL (oxLDL).

Function

OLR1 is a receptor for oxLDL and has a role in the development of atherosclerosis, a disease in which plaque builds up inside your arteries. It is expressed in endothelial cells, smooth muscle cells, and macrophages, which are all involved in atherogenesis. The binding of oxLDL to OLR1 has been shown to induce the expression of several genes, including inflammatory cytokines and MMPs, which contribute to the pathogenesis of atherosclerosis.

Clinical significance

Alterations in the OLR1 gene have been associated with an increased risk of coronary artery disease and myocardial infarction. In addition, OLR1 has been implicated in the pathogenesis of other diseases, such as diabetes mellitus and Alzheimer's disease, due to its role in the inflammatory response and oxidative stress.

Research

Research on OLR1 has focused on its role in atherosclerosis and other diseases, as well as its potential as a therapeutic target. Studies have shown that blocking the activity of OLR1 can reduce atherosclerosis in animal models, suggesting that it may be a promising target for the treatment of cardiovascular disease.

See also

• Low-density lipoprotein
• Atherosclerosis
• Coronary artery disease
• Myocardial infarction
• Diabetes mellitus
• Alzheimer's disease