Afurolol

Afurolol is a beta-adrenergic antagonist (beta-blocker) used in the treatment of various cardiovascular diseases. It is known for its ability to manage hypertension, angina pectoris, and certain types of arrhythmias.

Pharmacology

Afurolol works by blocking the action of epinephrine and norepinephrine on beta-adrenergic receptors, which are part of the sympathetic nervous system. This action results in a decrease in heart rate, myocardial contractility, and blood pressure, making it effective in the management of cardiovascular conditions.

Indications

Afurolol is primarily indicated for:

• Hypertension: It helps in lowering high blood pressure, reducing the risk of stroke and myocardial infarction.
• Angina pectoris: It alleviates chest pain by reducing the heart's demand for oxygen.
• Arrhythmias: It is used to manage abnormal heart rhythms by stabilizing the electrical activity of the heart.

Mechanism of Action

Afurolol selectively blocks beta-1 adrenergic receptors in the heart, which leads to a reduction in heart rate and cardiac output. This action helps in lowering blood pressure and reducing the workload on the heart.

Side Effects

Common side effects of Afurolol include:

• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Fatigue
• Dizziness
• Cold extremities

Contraindications

Afurolol should not be used in patients with:

• Asthma or chronic obstructive pulmonary disease (COPD)
• Severe bradycardia
• Cardiogenic shock
• Heart block greater than first degree

Dosage

The dosage of Afurolol varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally, and the dosage is adjusted based on the therapeutic response and the occurrence of side effects.

See Also

• Beta-blocker
• Hypertension
• Angina pectoris
• Arrhythmia

References

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