Desmethylclomipramine

Desmethylclomipramine is a tricyclic antidepressant (TCA) and the major active metabolite of clomipramine. It is primarily used in the treatment of depression and obsessive-compulsive disorder (OCD).

Pharmacology

Desmethylclomipramine acts by inhibiting the reuptake of serotonin and norepinephrine, thereby increasing the levels of these neurotransmitters in the brain. It also has significant anticholinergic effects, which can lead to side effects such as dry mouth, constipation, and blurred vision.

Clinical Use

Desmethylclomipramine is primarily used in the treatment of depression and obsessive-compulsive disorder. It may also be used off-label for the treatment of panic disorder, chronic pain, and enuresis (involuntary urination).

Side Effects

Common side effects of desmethylclomipramine include dry mouth, constipation, blurred vision, and dizziness. More serious side effects can include cardiac arrhythmias, orthostatic hypotension (a drop in blood pressure upon standing), and seizures.

Interactions

Desmethylclomipramine can interact with a number of other medications, including other antidepressants, antipsychotics, and certain heart medications. It is also contraindicated in individuals with a history of cardiac arrhythmias or other serious heart conditions.

See Also

• Clomipramine
• Tricyclic antidepressant
• Serotonin
• Norepinephrine