Norclomipramine

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Norclomipramine

Norclomipramine is a tricyclic antidepressant (TCA) and the major active metabolite of clomipramine. It is a secondary amine and is a dibenzazepine derivative.

Pharmacology

Norclomipramine acts by inhibiting the reuptake of both serotonin and norepinephrine, increasing the levels of these neurotransmitters in the brain. This action is believed to be responsible for the drug's antidepressant and anxiolytic effects.

Norclomipramine also has significant anticholinergic effects, which can lead to a variety of side effects such as dry mouth, constipation, urinary retention, and cognitive/memory impairment. It also has antiadrenergic and antihistamine effects.

Clinical Use

Norclomipramine is not typically used on its own in clinical practice, but its presence and activity are important in patients taking clomipramine. The levels of norclomipramine in the body can vary widely among individuals, and this can significantly affect the overall effects of clomipramine treatment.

Side Effects

The side effects of norclomipramine are similar to those of other tricyclic antidepressants. These can include dry mouth, blurred vision, constipation, urinary retention, rapid heartbeat, and cognitive/memory impairment. More serious side effects can include cardiac arrhythmias, seizures, and an increased risk of suicide.

See Also

• Clomipramine
• Tricyclic antidepressant
• Serotonin
• Norepinephrine