Saripidem
Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem. It has sedative effects and is used for the treatment of insomnia.
Pharmacology[edit | edit source]
Saripidem, like other drugs in the imidazopyridine family, works by enhancing the action of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. It does this by binding to the benzodiazepine site on the GABAA receptor, increasing the opening frequency of the receptor's chloride ion channel and allowing more chloride ions to enter the neuron. This makes the neuron less excitable and produces a calming effect.
Medical uses[edit | edit source]
Saripidem is primarily used for the treatment of insomnia. It helps to reduce the time it takes to fall asleep and increases the length of sleep. It is also used to treat certain types of anxiety disorders, although this use is less common.
Side effects[edit | edit source]
Like all drugs, saripidem can cause side effects. The most common side effects are dizziness, headache, nausea, and daytime drowsiness. Less common side effects include memory impairment, hallucinations, and changes in behavior. In rare cases, saripidem can cause severe allergic reactions.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
