Epanolol
Overview of the beta-blocker Epanolol
Epanolol | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Epanolol is a beta-adrenergic blocker used primarily in the treatment of hypertension and angina pectoris. It is a selective beta-1 adrenergic receptor antagonist, which means it primarily affects the heart and reduces its workload by slowing down the heart rate and decreasing the force of contraction.
Pharmacology[edit | edit source]
Epanolol works by blocking the action of epinephrine and norepinephrine on the beta-1 adrenergic receptors in the heart. This action leads to a decrease in heart rate, cardiac output, and blood pressure, making it effective in managing conditions like hypertension and angina.
Mechanism of Action[edit | edit source]
Epanolol selectively binds to beta-1 adrenergic receptors, which are predominantly found in cardiac tissue. By inhibiting these receptors, epanolol reduces the effects of sympathetic nervous system stimulation, leading to decreased heart rate and myocardial contractility.
Clinical Uses[edit | edit source]
Epanolol is primarily used in the management of:
It may also be used off-label for other cardiovascular conditions where beta-blockade is beneficial.
Side Effects[edit | edit source]
Common side effects of epanolol include:
Less common but more serious side effects can include:
- Heart failure
- Bronchospasm in patients with asthma
Synthesis[edit | edit source]
The synthesis of epanolol involves several chemical reactions, as depicted in the accompanying diagram. The process typically starts with the preparation of the appropriate aromatic amine, followed by a series of reactions to introduce the necessary functional groups and achieve the final beta-blocker structure.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD