Agouti-related peptide
Agouti-related peptide (also known as AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only produced in neurons and is known for its role in the regulation of food intake and energy balance.
Function[edit | edit source]
AgRP is involved in the regulation of feeding behavior and energy homeostasis. It is an endogenous antagonist of the melanocortin receptors MC3R and MC4R, and it stimulates food intake and reduces energy expenditure. AgRP is expressed in the arcuate nucleus of the hypothalamus, where it is co-expressed with Neuropeptide Y.
Role in disease[edit | edit source]
Alterations in AgRP function have been implicated in obesity and anorexia nervosa. In obesity, increased AgRP levels may contribute to excessive food intake and reduced energy expenditure. In anorexia nervosa, decreased AgRP levels may contribute to reduced food intake and increased energy expenditure.
Research[edit | edit source]
Research is ongoing to understand the precise role of AgRP in feeding behavior and energy homeostasis, and to develop potential treatments for obesity and eating disorders based on modulating AgRP function.
See also[edit | edit source]
References[edit | edit source]
| Agouti-related peptide Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
