Butobarbital

Butobarbital is a barbiturate derivative that has been used as a sedative and hypnotic agent. It is known for its ability to depress the central nervous system, leading to effects ranging from mild sedation to total anesthesia.

Chemical Properties

Butobarbital, also known as butethal, is chemically classified as a barbiturate. Barbiturates are derivatives of barbituric acid and are known for their CNS depressant properties. The chemical structure of butobarbital includes a pyrimidine ring fused with a urea moiety, which is typical of barbiturates.

Pharmacology

Butobarbital works by enhancing the activity of the gamma-aminobutyric acid (GABA) neurotransmitter at the GABA_A receptor. This action increases the influx of chloride ions into neurons, leading to hyperpolarization and decreased neuronal excitability. The result is a sedative effect that can progress to hypnosis and anesthesia at higher doses.

Medical Uses

Butobarbital has been used primarily for its sedative and hypnotic properties. It is prescribed for the short-term treatment of insomnia and for preoperative sedation. However, due to the risk of dependence and the availability of safer alternatives, its use has declined.

Side Effects

Common side effects of butobarbital include drowsiness, dizziness, and headache. More severe side effects can include respiratory depression, hypotension, and allergic reactions. Long-term use can lead to tolerance and dependence.

Legal Status

The legal status of butobarbital varies by country. In many places, it is classified as a controlled substance due to its potential for abuse and dependence.

History

Butobarbital was first synthesized in the early 20th century and was widely used for its sedative properties. However, with the development of newer, safer sedative-hypnotic agents, its use has significantly decreased.

See Also

• Barbiturate
• Sedative
• Hypnotic
• Insomnia
• GABA_A receptor