Allobarbital

Allobarbital is a barbiturate that was first synthesized in 1912 by two German chemists, Ernst Preiswerk and Paul T. Trost. It is an alkaloid that is used as a sedative and a hypnotic. Allobarbital, also known as diallylbarbituric acid, is a white, crystalline substance that is slightly soluble in water.

History

Allobarbital was first synthesized in 1912 by German chemists Ernst Preiswerk and Paul T. Trost. It was used in the early 20th century as a treatment for insomnia and anxiety. However, due to its potential for addiction and overdose, it has largely been replaced by safer and more effective medications.

Pharmacology

Allobarbital works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits the activity of the nervous system. This results in a decrease in anxiety, sedation, and hypnosis.

Medical uses

Allobarbital is used as a sedative and a hypnotic. It is also used in the treatment of insomnia and anxiety. However, due to its potential for addiction and overdose, it is not commonly used today.

Side effects

The side effects of allobarbital include drowsiness, dizziness, nausea, and vomiting. In severe cases, it can cause respiratory depression, coma, and death.

See also

• Barbiturate
• GABA
• Insomnia
• Anxiety

Allobarbital Resources
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