Clocapramine

Clocapramine is a type of antipsychotic medication that is classified as a dibenzazepine derivative. It was developed in the 1960s by the Japanese pharmaceutical company Yamanouchi Pharmaceutical Co. and is primarily used in Japan and Hong Kong. Clocapramine is used to treat a variety of mental health conditions, including schizophrenia, anxiety disorders, and mood disorders.

Etymology[edit | edit source]

The name "clocapramine" is derived from the chemical structure of the drug, which is a dibenzazepine derivative. The "clo" in clocapramine refers to the chlorine atom in its structure, while "capramine" is a common suffix used in the names of antipsychotic medications.

Pharmacology[edit | edit source]

Clocapramine acts as an antagonist at several receptors in the brain, including dopamine receptors, serotonin receptors, and adrenergic receptors. It has a high affinity for the D2 and D3 dopamine receptors, which are thought to be involved in the pathophysiology of schizophrenia. Clocapramine also has a high affinity for the 5-HT2A and 5-HT2C serotonin receptors, which may contribute to its efficacy in treating anxiety and mood disorders.

Side Effects[edit | edit source]

Like all antipsychotic medications, clocapramine can cause a range of side effects. These can include drowsiness, dizziness, dry mouth, constipation, and weight gain. In rare cases, clocapramine can cause more serious side effects such as tardive dyskinesia, a condition characterized by involuntary movements of the face and body.

Related Terms[edit | edit source]

Clocapramine Resources
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