Flucindole

Flucindole

Flucindole is a dopamine antagonist with antipsychotic properties that has been used in the treatment of schizophrenia. It is a member of the indole class of antipsychotic medications, which also includes molindone, loxapine, and aripiprazole.

Pharmacology

Flucindole acts primarily as a dopamine D2 receptor antagonist, which is thought to be responsible for its antipsychotic effects. It may also have some activity at other dopamine receptors, as well as at various serotonin receptors. The exact mechanism of action of flucindole, like that of other antipsychotics, is not fully understood.

Clinical Use

Flucindole has been used in the treatment of schizophrenia and other psychotic disorders. It may also be used in the management of bipolar disorder, particularly during manic episodes. The efficacy of flucindole in these indications is comparable to that of other antipsychotic medications.

Side Effects

Common side effects of flucindole include drowsiness, dizziness, and dry mouth. Less common side effects can include extrapyramidal symptoms such as tardive dyskinesia, akathisia, and parkinsonism. As with other antipsychotic medications, flucindole carries a risk of neuroleptic malignant syndrome, a potentially life-threatening condition.

See Also

• Antipsychotic
• Dopamine antagonist
• Schizophrenia
• Bipolar disorder