Aripiprazole/sertraline

Aripiprazole/sertraline is a combination medication used in the treatment of mental health disorders. It contains two active ingredients: aripiprazole, an antipsychotic, and sertraline, a selective serotonin reuptake inhibitor (SSRI). This combination is typically used when a patient does not respond adequately to monotherapy with either aripiprazole or sertraline.

Mechanism of Action

Aripiprazole works by modulating the activity of dopamine and serotonin in the brain. It is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors.

Sertraline, on the other hand, is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Indications

Aripiprazole/sertraline is indicated for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, and post-traumatic stress disorder (PTSD). It may also be used off-label for other conditions as determined by a healthcare provider.

Side Effects

Common side effects of aripiprazole/sertraline include nausea, vomiting, diarrhea, constipation, weight gain, and dizziness. More serious side effects may include suicidal thoughts, unusual changes in behavior, and signs of an allergic reaction.

Contraindications

Aripiprazole/sertraline should not be used in patients with a known hypersensitivity to either aripiprazole or sertraline. It is also contraindicated in patients with a history of serotonin syndrome or neuroleptic malignant syndrome.

Interactions

Aripiprazole/sertraline may interact with other medications, including other antidepressants, antipsychotics, and certain types of antibiotics. It is important to inform your healthcare provider of all medications you are currently taking.

Dosage and Administration

The dosage of aripiprazole/sertraline is individualized based on the patient's condition and response to treatment. It is typically taken once daily, with or without food.

See Also

• Antipsychotic
• Selective serotonin reuptake inhibitor
• Major depressive disorder
• Obsessive-compulsive disorder
• Panic disorder
• Post-traumatic stress disorder