Clebopride

Clebopride

Clebopride is a drug used primarily as a gastroprokinetic agent, which means it enhances the motility of the gastrointestinal tract. It is classified under the benzamide derivatives, a group of drugs known for their prokinetic properties. Clebopride is also known to have antiemetic properties, making it useful in the treatment of nausea and vomiting.

Pharmacology

Clebopride acts by blocking dopamine receptors in the dopaminergic pathways of the brain. This blockade results in an increase in the release of acetylcholine, a neurotransmitter that stimulates gastrointestinal motility. The drug's antiemetic properties are also due to its dopamine receptor blockade, specifically in the chemoreceptor trigger zone (CTZ) of the brain, which is involved in the induction of nausea and vomiting.

Clinical Uses

Clebopride is used in the treatment of various gastrointestinal disorders such as gastroesophageal reflux disease (GERD), gastroparesis, and functional dyspepsia. It is also used to manage nausea and vomiting caused by other medications, particularly those used in chemotherapy and radiation therapy for cancer treatment.

Side Effects

The most common side effects of Clebopride include drowsiness, dry mouth, and constipation. Rare but serious side effects include tardive dyskinesia, a disorder characterized by involuntary movements, and neuroleptic malignant syndrome, a potentially life-threatening reaction to antipsychotic drugs.

Contraindications

Clebopride is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation.

See Also

• Metoclopramide
• Domperidone
• Cisapride