Clopimozide

Clopimozide is an antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the class of drugs known as dopamine antagonists, which work by blocking the action of dopamine, a neurotransmitter in the brain.

Pharmacology

Clopimozide acts as a potent antagonist of the D2 receptor, a subtype of the dopamine receptor. By blocking the action of dopamine, it reduces the symptoms of schizophrenia and other psychotic disorders. It also has some anticholinergic effects, which can lead to side effects such as dry mouth and constipation.

Clinical Use

Clopimozide is used in the treatment of schizophrenia and other psychotic disorders. It can help to reduce symptoms such as hallucinations, delusions, and disorganized thinking. However, it is not a cure for these conditions and is typically used as part of a comprehensive treatment plan that may also include psychotherapy and other medications.

Side Effects

Common side effects of clopimozide include drowsiness, dizziness, and dry mouth. More serious side effects can include tardive dyskinesia, a condition characterized by involuntary movements, and neuroleptic malignant syndrome, a rare but potentially life-threatening reaction to antipsychotic drugs.

Contraindications

Clopimozide should not be used in patients with a known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with certain heart conditions, as it can cause QT prolongation, a serious heart rhythm disorder.

See Also

• Antipsychotic
• Schizophrenia
• Dopamine antagonist
• D2 receptor
• Tardive dyskinesia
• Neuroleptic malignant syndrome