PD-168,077

PD-168,077

Chemical structure of PD-168,077

PD-168,077 is a chemical compound that acts as a selective agonist for the dopamine receptor D4. It is primarily used in scientific research to study the role of the D4 receptor in various physiological and neurological processes.

Pharmacology

PD-168,077 is known for its high affinity and selectivity towards the dopamine receptor D4, which is one of the five subtypes of dopamine receptors. The D4 receptor is a G protein-coupled receptor that is involved in the modulation of neurotransmission in the central nervous system.

Mechanism of Action

PD-168,077 binds to the D4 receptor and mimics the action of dopamine, the natural ligand for this receptor. By activating the D4 receptor, PD-168,077 can influence various signaling pathways that are involved in cognition, emotion, and behavior.

Research Applications

PD-168,077 is used in research to explore the potential therapeutic applications of D4 receptor modulation. Studies have investigated its effects on schizophrenia, attention deficit hyperactivity disorder (ADHD), and other neuropsychiatric disorders.

Schizophrenia

Research has suggested that the D4 receptor may play a role in the pathophysiology of schizophrenia. PD-168,077 has been used in animal models to study its effects on dopaminergic signaling and its potential to alleviate symptoms associated with this disorder.

ADHD

The D4 receptor has also been implicated in ADHD, and PD-168,077 is used to investigate how modulation of this receptor can affect attention and hyperactivity in preclinical models.

Chemical Properties

PD-168,077 is a small molecule with a specific chemical structure that allows it to selectively bind to the D4 receptor. The structure of PD-168,077 is depicted in the image to the right.

Related Pages

• Dopamine receptor
• G protein-coupled receptor
• Neurotransmitter
• Schizophrenia
• Attention deficit hyperactivity disorder