Nemonapride

Nemonapride is an antipsychotic agent used in the treatment of schizophrenia. It is a dopamine antagonist and specifically blocks D2 receptors and serotonin 5-HT1A receptors, which is thought to have beneficial effects on the negative symptoms of schizophrenia.

Pharmacology

Nemonapride acts as an antagonist at the D2 receptor, which is found in the brain. In particular, it has high affinity for the D2 receptors in the mesolimbic pathway, which is associated with the effects of antipsychotic drugs. Nemonapride also has high affinity for the 5-HT1A receptor, which is thought to contribute to its effects on negative symptoms and cognitive function.

Clinical use

Nemonapride is used in the treatment of schizophrenia. It has been found to be effective in reducing both the positive and negative symptoms of the disease. The drug is also used in the treatment of other psychiatric disorders, such as bipolar disorder and major depressive disorder.

Side effects

The most common side effects of nemonapride are extrapyramidal symptoms, which include tremor, rigidity, and bradykinesia. Other side effects can include insomnia, anxiety, and nausea. In rare cases, nemonapride can cause neuroleptic malignant syndrome, a potentially life-threatening condition.

See also

• Antipsychotic
• Dopamine antagonist
• Serotonin receptor antagonist

Nemonapride Resources
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