SKF-83,959

SKF-83,959 is a synthetic compound of the benzazepine chemical class which acts as a D1/D5 receptor full agonist, and produces a characteristic stimulant effect in animals, distinct from that of other known stimulant drugs.

Pharmacology

SKF-83,959 is a full agonist at the D1-D5 dopamine receptors, meaning it fully activates these receptors in the absence of the endogenous ligand, dopamine. It is also a sigma receptor agonist, and its psychotomimetic effects such as hallucinations and thought disorder may be mediated by this action.

Clinical significance

The compound has been investigated for its potential use in the treatment of Parkinson's disease, although it has not yet been approved for this use. It has also been studied for potential antipsychotic effects, but these studies have not yet led to the development of a clinically used drug.

See also

• Dopamine agonist
• Sigma receptor

References

SKF-83,959 Resources
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