WAY-100,635
WAY-100,635 is a compound that is used in scientific research. It acts as an antagonist for the 5-HT1A receptor, and is most commonly used in animal studies to help understand the function of this receptor.
Chemistry[edit | edit source]
WAY-100,635 is a piperazine derivative. It has a high affinity for the 5-HT1A receptor, and is selective for this receptor over other serotonin receptors. The compound is radiolabeled with carbon-11 for use in positron emission tomography (PET) studies.
Pharmacology[edit | edit source]
In pharmacological studies, WAY-100,635 has been shown to block the effects of agonist drugs at the 5-HT1A receptor. This has been useful in studies investigating the role of this receptor in various behaviors, including anxiety, depression, and aggression.
Research Use[edit | edit source]
WAY-100,635 is used in research to help understand the function of the 5-HT1A receptor. It is often used in combination with PET to visualize the distribution of 5-HT1A receptors in the brain. This has been particularly useful in studies investigating the role of these receptors in psychiatric disorders such as depression and anxiety.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
