WAY-100635

WAY-100635 is a compound that is used in scientific research. It acts as an antagonist for the 5-HT1A receptor, and has been used in the development of various drugs. WAY-100635 is also a potent and selective 5-HT1A receptor antagonist, with a Ki of 0.91 nM at the human 5-HT1A receptor and over 100-fold selectivity over other receptors.

History

WAY-100635 was first synthesized in the early 1990s by the pharmaceutical company Warner-Lambert. It was initially developed as a potential treatment for depression and anxiety, but its use has since expanded to include research into other areas of neuroscience.

Pharmacology

WAY-100635 is a potent and selective antagonist for the 5-HT1A receptor. It has a high affinity for this receptor, with a Ki of 0.91 nM. This makes it one of the most potent 5-HT1A receptor antagonists currently available. In addition to its high affinity, WAY-100635 also has over 100-fold selectivity for the 5-HT1A receptor over other receptors.

Uses

WAY-100635 is primarily used in scientific research. It is often used in studies investigating the role of the 5-HT1A receptor in various neurological and psychiatric disorders. These include depression, anxiety, schizophrenia, and Parkinson's disease.

See also

• 5-HT1A receptor
• Antagonist (biochemistry)
• Neuroscience

References

WAY-100635 Resources
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