Trifluperidol
Trifluperidol is a typical antipsychotic medication belonging to the butyrophenone class. It is primarily used in the treatment of schizophrenia and other forms of psychosis. Trifluperidol is known for its potent antipsychotic effects and is often used in cases where other antipsychotic medications have proven ineffective.
Pharmacology[edit | edit source]
Trifluperidol works by blocking dopamine receptors in the brain, particularly the D2 receptors. This action helps to reduce the symptoms of psychosis, such as hallucinations and delusions. The medication also has some affinity for other receptors, including serotonin and histamine receptors, which may contribute to its overall effects and side effect profile.
Indications[edit | edit source]
Trifluperidol is indicated for the treatment of:
- Schizophrenia
- Severe psychosis
- Acute mania in bipolar disorder
Side Effects[edit | edit source]
Common side effects of trifluperidol include:
- Extrapyramidal symptoms (EPS) such as tremors, rigidity, and bradykinesia
- Sedation
- Weight gain
- Dry mouth
- Constipation
Serious side effects may include:
Dosage[edit | edit source]
The dosage of trifluperidol varies depending on the severity of the condition being treated and the response of the patient. It is typically administered in low doses initially, with gradual increases as needed. The medication can be given orally or via intramuscular injection.
Contraindications[edit | edit source]
Trifluperidol is contraindicated in patients with:
- Known hypersensitivity to trifluperidol or other butyrophenones
- Severe central nervous system depression
- Parkinson's disease
History[edit | edit source]
Trifluperidol was developed in the 1950s and has been used in clinical practice since then. It is one of the many antipsychotic medications that were developed during this period to provide more effective treatment options for patients with severe mental illnesses.
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References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD