Moperone

Moperone is a typical antipsychotic medication that belongs to the butyrophenone class of drugs. It is primarily used in the treatment of schizophrenia and other psychotic disorders. Moperone is not widely used due to its potential side effects and the availability of safer alternatives.

Pharmacology

Moperone acts by blocking dopamine receptors in the brain, specifically the D2 subtype. This reduces the overactivity of dopamine, which is thought to be a contributing factor in the development of psychotic symptoms. Moperone also has some affinity for the D1 subtype, but this is less significant in terms of its antipsychotic effects.

Clinical Use

Moperone is used in the treatment of schizophrenia and other psychotic disorders. It can help to reduce symptoms such as hallucinations, delusions, and disorganized thinking. However, it is not a first-line treatment and is typically only used when other antipsychotic medications have not been effective.

Side Effects

The side effects of Moperone can include extrapyramidal symptoms such as tremors, rigidity, and bradykinesia. It can also cause tardive dyskinesia, a condition characterized by involuntary movements of the face and body. Other potential side effects include sedation, weight gain, and anticholinergic effects such as dry mouth and blurred vision.

History

Moperone was first synthesized in the 1960s as part of a series of butyrophenone derivatives. It was initially marketed as a potent antipsychotic with fewer side effects than older drugs in the same class. However, its use has declined over time due to the development of newer, safer antipsychotic medications.

See Also

• Antipsychotic
• Butyrophenone
• Schizophrenia
• Psychotic disorders