Melperone
Melperone is an atypical antipsychotic and sedative that is used in the treatment of schizophrenia and other psychotic disorders. It is also used as a sleep aid due to its sedative properties. Melperone is marketed under the brand name Buronil.
Etymology[edit]
The term "Melperone" is derived from the chemical name of the drug, which is 4'-((2-methyl-1-propyl)-3-piperidyl)-2-benzyl-1,1-diphenylbutylone.
Pharmacology[edit]
Melperone acts as an antagonist at various dopamine, serotonin, and adrenergic receptors. It has a high affinity for the D2, 5-HT2A, 5-HT2C, and α1-adrenergic receptors, and a moderate affinity for the D1, D3, D4, 5-HT1A, 5-HT6, and α2-adrenergic receptors.
Medical uses[edit]
Melperone is used in the treatment of various psychiatric disorders including schizophrenia, acute and chronic psychosis, and agitated states. It is also used as a sleep aid due to its sedative properties.
Side effects[edit]
Common side effects of Melperone include drowsiness, dizziness, dry mouth, and weight gain. Less common side effects include extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome.
History[edit]
Melperone was first synthesized in the 1960s by the German pharmaceutical company Hoechst AG. It was first marketed in Europe in the 1970s under the brand name Buronil.
See also[edit]
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