SB-277,011-A

SB-277,011-A is a drug that is used in scientific research. It is a selective, orally available antagonist of the dopamine D3 receptor. It has been shown to increase the reinforcing effects of cocaine in rats, suggesting a role for D3 receptors in cocaine addiction.

Pharmacology

SB-277,011-A is a selective antagonist of the dopamine D3 receptor. It has a 100-fold selectivity for D3 receptors over D2 receptors. The drug is orally available and has been used in scientific research to investigate the role of D3 receptors in various behaviors.

Research

Research has shown that SB-277,011-A can increase the reinforcing effects of cocaine in rats. This suggests that D3 receptors may play a role in cocaine addiction. Other research has shown that the drug can reduce the self-administration of nicotine in rats, suggesting a potential role for D3 receptors in nicotine addiction as well.

See also

• Dopamine receptor D3
• Dopamine antagonist

References

SB-277,011-A Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski