Monoamine-depleting agent

Monoamine-depleting agents are a class of drugs that reduce the levels of monoamines in the body. Monoamines are a group of neurotransmitters and neuromodulators that contain one amino group connected to an aromatic ring by a two-carbon chain. The primary monoamines are dopamine, norepinephrine, and serotonin.

Mechanism of Action

Monoamine-depleting agents work by inhibiting the synthesis of monoamines or by blocking their reuptake into the presynaptic neuron, thereby reducing their levels in the synaptic cleft and ultimately in the body. This can have a variety of effects depending on the specific monoamine that is being depleted and the area of the brain where this depletion is occurring.

Uses

Monoamine-depleting agents are used in the treatment of a variety of conditions. For example, they can be used to treat mood disorders such as depression and anxiety, as they can help to balance out the levels of monoamines in the brain. They can also be used in the treatment of Parkinson's disease, as they can help to reduce the levels of dopamine, which is often elevated in this condition.

Side Effects

The side effects of monoamine-depleting agents can vary depending on the specific drug and the individual patient. However, common side effects can include nausea, dizziness, and fatigue. In some cases, these drugs can also cause more serious side effects such as suicidal thoughts or behaviors.

Examples

Examples of monoamine-depleting agents include reserpine, which depletes the levels of norepinephrine, dopamine, and serotonin, and tetrabenazine, which depletes the levels of dopamine.

See Also

• Monoamine neurotransmitter
• Neurotransmitter
• Pharmacology