Pipamperone

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Pipamperone (INN, USAN, BAN), also known as pipamperon, is a typical antipsychotic and sedative that has been used in the treatment of schizophrenia and as a sleep aid. It is not commonly used in the United States or Canada, but is used in various countries worldwide, including Europe and South Africa.

Etymology[edit]

The term "pipamperone" is derived from the chemical name of the drug, which is 1-(4-fluorophenyl)-4-(4-piperidyl)-4-piperidone.

Pharmacology[edit]

Pipamperone acts as an antagonist at the D2 and D3 receptors, and is also a potent 5-HT2A antagonist. The drug has negligible affinity for the H1 and M1 receptors.

Medical uses[edit]

Pipamperone is used in the treatment of psychosis, particularly those of schizophrenia, and manic phases of bipolar disorder. It is also used to treat insomnia and other conditions with anxiety and/or agitation.

Side effects[edit]

Common side effects of pipamperone include drowsiness, weight gain, dry mouth, constipation, and tachycardia. Rare side effects include extrapyramidal symptoms, neuroleptic malignant syndrome, and QT interval prolongation.

See also[edit]

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Pipamperone[edit]

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