Perphenazine decanoate

Perphenazine decanoate is a long-acting injectable antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It is a derivative of perphenazine, a typical antipsychotic drug, with the addition of a decanoate ester to improve its longevity.

Pharmacology

Perphenazine decanoate is a dopamine antagonist, which means it works by blocking dopamine receptors in the brain. Dopamine is a neurotransmitter that is involved in regulating mood and behavior. By blocking its action, perphenazine decanoate can help to reduce symptoms such as hallucinations, delusions, and disorganized thinking that are characteristic of psychotic disorders.

Clinical Use

Perphenazine decanoate is administered by intramuscular injection, typically once every two to four weeks. This long-acting formulation is particularly useful for patients who have difficulty adhering to daily oral medication regimens. It is used in the treatment of chronic psychotic disorders such as schizophrenia, as well as in the management of severe nausea and vomiting in palliative care settings.

Side Effects

Like all antipsychotic medications, perphenazine decanoate can cause side effects. These may include drowsiness, dizziness, dry mouth, constipation, and blurred vision. More serious side effects can include movement disorders such as tardive dyskinesia, and potentially life-threatening conditions such as neuroleptic malignant syndrome.

See Also

• Perphenazine
• Antipsychotic
• Schizophrenia
• Psychotic disorders
• Dopamine antagonist