BD1063

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BD1063 is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor, and 702 ± 147 nM for the sigma-2 receptor. It has been shown to reduce the effects of methamphetamine in animal studies.

Pharmacology[edit | edit source]

BD1063 is a drug which acts as an antagonist for sigma receptors. It is selective for the sigma-1 subtype, and has less affinity for the sigma-2 subtype. Sigma receptors are a set of proteins located in the brain, which are thought to be involved in various drug effects and diseases, including schizophrenia, depression, and drug addiction.

Effects[edit | edit source]

BD1063 has been shown to reduce the self-administration of methamphetamine in rats, suggesting that it may have potential for use in the treatment of methamphetamine addiction. It has also been shown to produce antidepressant-like effects in animal studies, suggesting potential applications in the treatment of depression.

See also[edit | edit source]

References[edit | edit source]


BD1063 Resources

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Contributors: Prab R. Tumpati, MD