BD-1063

BD-1063 is a chemical compound that acts as a selective sigma-1 receptor antagonist. It is primarily used in scientific research to study the role of sigma-1 receptors in various physiological and pathological processes.

Chemical Properties

BD-1063 has the chemical formula C_21H_26N_2O and a molecular weight of 322.45 g/mol. It is a member of the class of compounds known as benzamides.

Pharmacology

BD-1063 is known for its high affinity and selectivity for the sigma-1 receptor, a type of sigma receptor that is involved in the modulation of neurotransmitter systems, ion channels, and cell signaling pathways. By blocking the sigma-1 receptor, BD-1063 can influence various biological processes, including pain perception, neuroprotection, and drug addiction.

Research Applications

BD-1063 is widely used in preclinical research to investigate the role of sigma-1 receptors in different conditions. Some of the key areas of research include:

• Neuropathic pain: Studies have shown that BD-1063 can reduce pain behaviors in animal models of neuropathic pain.
• Neurodegenerative diseases: Research suggests that sigma-1 receptor antagonists like BD-1063 may have potential therapeutic effects in diseases such as Alzheimer's disease and Parkinson's disease.
• Substance abuse: BD-1063 has been used to study the involvement of sigma-1 receptors in the reinforcing effects of drugs like cocaine and methamphetamine.

Safety and Toxicity

The safety profile of BD-1063 has been evaluated in various animal studies. While it is generally well-tolerated at research doses, the long-term effects and potential toxicity in humans are not well understood.

Related Compounds

BD-1063 is part of a broader class of sigma receptor ligands, which includes both agonists and antagonists. Other notable sigma-1 receptor antagonists include BD-1047 and NE-100.

See Also

• Sigma receptor
• Sigma-1 receptor
• Neurotransmitter
• Ion channel
• Cell signaling
• Neuropathic pain
• Neurodegenerative diseases
• Substance abuse

External Links

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