3-MeO-PCE

3-MeO-PCE

Chemical structure of 3-MeO-PCE

3-Methoxyeticyclidine (3-MeO-PCE) is a dissociative anesthetic of the arylcyclohexylamine class. It is chemically related to phencyclidine (PCP) and methoxetamine (MXE), and is known for its psychoactive effects. 3-MeO-PCE is used in research settings and has been encountered as a designer drug.

Chemical Structure and Properties

3-MeO-PCE is a derivative of eticyclidine (PCE), with a methoxy group at the 3-position of the phenyl ring. Its chemical formula is C15H23NO, and it has a molecular weight of 233.35 g/mol. The presence of the methoxy group is thought to influence its pharmacological properties, differentiating it from other arylcyclohexylamines.

Pharmacology

3-MeO-PCE acts primarily as an NMDA receptor antagonist, similar to other dissociatives like ketamine and PCP. This action is responsible for its dissociative effects, which include analgesia, anesthesia, and hallucinations. The compound may also interact with other neurotransmitter systems, contributing to its complex psychotropic profile.

Effects

The effects of 3-MeO-PCE can vary depending on the dose and individual sensitivity. Common effects include:

• Dissociation and depersonalization
• Euphoria and stimulation
• Altered perception of time and space
• Visual and auditory hallucinations
• Cognitive and memory impairment

At higher doses, 3-MeO-PCE can cause more intense dissociative states, which may be accompanied by motor impairment and nausea.

Legal Status

The legal status of 3-MeO-PCE varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of approved medical use. In others, it may be unscheduled but subject to analogue laws.

Safety and Risks

The use of 3-MeO-PCE carries several risks, particularly at high doses or when combined with other substances. Potential risks include:

• Psychosis and agitation
• Cardiovascular effects such as increased heart rate and blood pressure
• Respiratory depression
• Addiction and tolerance

Users should exercise caution and be aware of the potential for adverse reactions.

Related Compounds

3-MeO-PCE is part of a broader class of arylcyclohexylamines, which includes:

• Phencyclidine (PCP)
• Ketamine
• Methoxetamine (MXE)
• Dextromethorphan (DXM)

These compounds share similar mechanisms of action but differ in their potency, duration, and subjective effects.

Related Pages

• Dissociative drug
• NMDA receptor antagonist
• Designer drug